Biorbyt's Alpha Catenin antibody is a Mouse monoclonal antibody. The Alpha Catenin antibody was generated using catenin alpha 1, and CTNNA1 as the antigen. It reacts with Homo Sapiens, and Human. This antibody has been shown to work in applications such as: Cell Sorting, Isolation, Flow Cytometry, Immunofluorescence, and Western Blot.
Description
Recognizes a protein of 102kDa, identified as Catenin, alpha-1. Catenins comprise a large family of Ca2+-dependent, homotypic cell-cell adhesion molecules that play important roles in development, epithelial cell polarity and tumor progression. Alpha-Catenin is a key regulator of actin dynamics in cell-cell adhesion. During cell-cell adhesion, alpha-Catenin forms a heterodimer with beta-Catenin and links the cadherins to actin associated with the cytoskeleton. Alpha-Catenin also regulates the beta-Catenin signaling in various cells. It displays the tumor suppressor activity and is found to be down regulated in some forms of breast cancer